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Scientist I - Bioinformatics

Facility:  Research
Location: 

Seattle, WA, US

About the Department                                                                                                                                             

At Novo Nordisk Research Center Seattle, Inc. (NNRCSI) our scientists apply cutting-edge technologies to early R&D projects with the goal of bringing real change to People with Diabetes and Obesity. Your skills, dedication and ambition will help change lives for the better and you will work with extraordinary talent, continuously learn and develop, and drive changes to defeat serious chronic conditions. We recognize the importance of an enjoyable workplace, which stimulates a strong culture of ingenuity and innovation and our support of a healthy work-life balance adds to a best-in-class employee experience.  As a new focus area, we aim to build up a dynamic computational team, which will leverage structure-based design, computational biology and machine learning expertise to the drug discovery process.  Our aim is to strengthen target identification and drug design processes at NNRCSI and through global collaboration across our R&D sites. This team will implement state-of-the-art structural modelling and machine learning technologies to improve functional and biophysical properties of proteins, peptides and new molecular format for future therapies. They will build up bioinformatics expertise spanning areas from sequence analysis, computer vision and different omics and pathway analysis. This team will work in a flexible, cross-functional setting in close collaboration with experimentalists to drive pre-clinical projects with very ambitious scientific goals. They will have external collaborations with academic and biotech partners within computational drug discovery in North America.  We are changing lives for a living. Are you ready to make a difference?

 

The Position

The Bioinformatics Scientist will contribute to the Department of Computational Drug Discovery by designing studies and analyzing big data sets using machine learning and bioinformatic algorithms. . From these analyses the person will assist in identifying new potential drug targets, biomarkers, and tissue specific anchors, help elucidate molecular mode-of-action of new drug targets as well as increase understanding of disease mechanisms. The Scientist will collaborate with teams across the organization to design data-driven experiments, distill valuable findings, and plan next steps.  . Furthermore, the Scientist will communicate and educate colleagues around the organization in the utility of bioinformatic tools and design of experiments. This role will ensure that the department can execute cutting-edge algorithms within bioinformatics and establish the department as a recognized leader in this field by publishing articles, patents, or presenting research at conferences. 

 

Relationships

Reports to of the head of the computational drug discovery department. Internal relationships include project teams and research colleagues both in Seattle, Indianapolis and around the globe. Communicates data externally when required. May oversee parts of computational drug discovery operations and computational facilities. Individual Contributor: does not manage other employees.

 

Essential Functions

 

  • Design statistical and machine-learning models to analyze large-scale collections of sequence data 
  • Actively participate in design of experiments and critically evaluate setup and workflows 
  • Bring new insight to biological problems by applying new informatic algorithms 
  • Integrate transcriptomics data with other data (e.g. phenotypic, proteomics, metabolomics) 
  • Ensure awareness of recent success within bioinformatics and state-of-the-art machine learning 
  • Automate design and analysis pipelines for target screening and sequencing analysis 
  • Prepare and present research in top-leading journals or conferences. 
  • Prepare and present written and oral reports/dashboards to scientists and non-scientists. 

 

Physical Requirements:

Novo Nordisk requires all employees, both Field and Office-based, to be fully vaccinated with a COVID-19 vaccine prior to the first date of employment. As required by applicable law, Novo Nordisk will consider requests for reasonable accommodation for those unable to be vaccinated. You will be required to upload an image of your COVID-19 vaccine card at the time of hire and/or on your first day of employment

 

Qualifications

  • Bachelor 's Degree 12+ years’ relevant experience required.  Degree in Bioinformatics, Biostatistics, Computational Biology, or other relevant areas preferred.
  • Master’s degree  with 8+ years’ relevant experience, or a Doctoral degree with 2+ years’ post-doctoral and/or industry relevant experience can be considered
  • Relevant required experience includes:
    • Demonstrated experience working with high dimension datasets (e.g. single cell RNAseq, proteomics, or WGS data). 

    • Experience visualizing and communicating findings from large multidimensional data sets 

    • Experience with scripting languages (e.g. python, R) and linux/shell scripting  

    • Experience designing experiments 

  • Knowledge of machine learning and statistical analysis is required. 
  • Familiarity with predicting gene-disease associations is preferred. 
  • Experience with analysis and organization of spatial transcriptomics data is preferred.
  • Knowledge of database organization and structuring of sequence data is preferred.
  • Ability to work independently and in teams, and to collaborate with external parties
  • Excellent written and oral communication skills, ability to communicate with non-experts

 

Millions rely on us 
At Novo Nordisk, we don’t wait for change. We drive change. We’re a dynamic company in an even more dynamic industry, and we know that what got us to where we are today is not necessarily what will make us successful in the future. We embrace the spirit of experimentation, striving for excellence without fixating on perfection. We never shy away from opportunities to develop, we seize them. Working at Novo Nordisk is working toward something bigger than ourselves, and it’s a collective effort. Novo Nordisk relies on the joint potential and collaboration of its more than 40,000 employees to change the lives for the better for millions of patients living with diabetes and other chronic diseases. Together, we go further. Together, we’re life changing.

 

Novo Nordisk is an equal opportunity employer.  Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.

 

If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.