HTA Associate Statistical Director - Cross-Trial Evidence & HTA

Europe (Denmark, UK, Spain, or other major hub)

In rare disease, access decisions often depend on evidence generated under difficult conditions: small populations, limited head-to-head data, and evidence expectations that vary across markets. In this role, you will turn that complexity into statistical strategies that are scientifically credible, transparent and fit for HTA and payer decision-making.

Your new role

You will lead strategic HTA statistics across our rare disease portfolio, where methodological complexity meets high-stakes evidence generation and every statistical choice matters.

Rare disease HTA presents challenges that often require more than standard approaches. You will develop statistical strategies for comparative effectiveness where populations are small, direct comparative data may be limited, and every piece of evidence needs to work harder. As EU HTA joint clinical assessments reshape evidence requirements across Europe, you will help ensure that our approaches are coherent across assets, markets and functions.

Working across multiple assets and the full development lifecycle will give you portfolio-level scope: you will identify patterns others miss, build frameworks that scale, lead informally across functions and geographies, and see how your statistical strategies directly shape evidence plans and access outcomes.

Your key responsibilities include:

• Lead rare disease HTA statistical strategy from planning through delivery. Drive strategic statistical input to evidence generation plans, HTA submissions and payer evidence packages across the portfolio. Synthesise evidence across clinical trials, indirect treatment comparisons and real-world evidence, ensuring consistency, defensibility and transparency across the portfolio. Translate statistical requirements of AMNOG, NICE, HAS and EU HTA joint clinical assessments into what the data must demonstrate and how it must be analysed.
• Build methodological frameworks where standard approaches break down. Develop and validate statistical approaches for comparative effectiveness in small populations and with limited head-to-head data. Determine what's scientifically defensible and what HTA bodies will accept when textbook methods don't apply. Drive strategic oversight to ensure methodological coherence across the portfolio, with approaches that are scientifically rigorous, transparent and realistic given the evidence available.
• Influence without authority and build capability. Lead informally across biostatisticians, health economists, regulatory teams and affiliates worldwide through expertise and relationship-building. Represent the organisation at scientific advice meetings and HTA body interactions. Mentor team members, lead methodological working groups, contribute to publications, and drive knowledge sharing on rare disease HTA approaches.

Your skills and qualifications

• PhD in statistics, biostatistics, or related quantitative field (or MSc with equivalent depth of experience)
• Minimum 7 years pharmaceutical industry experience, with at least 3 years directly focused on HTA statistics and comparative effectiveness methods for market access
• Deep expertise in indirect treatment comparisons, network meta-analysis, and evidence synthesis methods, with demonstrated track record across major HTA frameworks and strong understanding of evolving HTA requirements including EU HTA regulation
• Emerging informal leader who delivers results through colleagues - ability to influence across functions and geographies, build alignment without formal authority, and lead through expertise, credibility and strong relationship-building
• Direct experience engaging with HTA bodies or payers on statistical and methodological matters, with strong scientific communication skills including publications and conference presentations
• Interest in rare disease evidence challenges - working where methodological creativity, strategic judgment and the ability to make limited evidence work harder matter as much as technical execution
• Ability to operate beyond individual projects, shaping portfolio-level approaches and reusable frameworks

Your new department

Cross-Trial Evidence & HTA (CTEHTA) is a specialist statistics and data science function of approximately 20 statisticians and data scientists, delivering evidence generation from early clinical development through launch and lifecycle management across the full Novo Nordisk portfolio.

We produce work that is scrutinised by HTA bodies, payers and the scientific community, which means transparency, auditability and methodological credibility are baseline requirements. When we get it right, the outcome is straightforward: the right medicines reach the right patients at the right time.

We are a small team where everyone's contribution is visible, which means high expectations but also high trust. You will have direct visibility into leadership decisions, your statistical judgment will shape evidence strategy across the rare disease portfolio, and the gap between having an idea and implementing it is short.

Working at Novo Nordisk

Every day we seek solutions that defeat serious chronic diseases. To do this, we approach our work with an unconventional spirit, rare determination, and constant curiosity. For over 100 years, this unordinary mindset has seen us build a company unlike any other. One where a collective passion for our purpose, mutual respect and a willingness to go beyond what we know delivers extraordinary results.

What we offer

There is, of course, more on offer here than the uniqueness of our culture and the extraordinary results we produce. Being part of a global healthcare company means opportunities to learn and develop are all around us, while our benefits are designed with your career and life stage in mind.

Salary: For this role, the Annual Base Salary ranges from DKK 847,000 to DKK 1,245,100, corresponding to the level of the position. The placement within the salary range will be assessed during the recruitment process based on the candidate’s skills, competencies, knowledge, and relevant experience.

Incentives and Benefits: The salary package may include short-term and/or long-term incentives as well as other employee benefits based on position level, location, functional area and relevant market benchmarks. Learn more about our Reward Philosophy here.

There is, of course, more on offer here than the uniqueness of our culture and the extraordinary results we produce. Being part of a global healthcare company means opportunities to learn and develop are all around us, while our benefits are designed with your career and life stage in mind.

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

At Novo Nordisk, we're not chasing quick fixes – we're creating lasting change for long-term health. For over 100 years, we've been driven by a single purpose: to defeat serious chronic diseases and help millions of people live healthier lives. This dedication fuels our constant curiosity and inspires us to push the boundaries of what's possible in healthcare. We embrace diverse perspectives, seek out bold ideas, and build partnerships rooted in shared purpose. Together, we're making healthcare more accessible, treating and preventing diseases, and pioneering solutions that create change spanning generations. When you join us, you become part of something bigger – a legacy of impact that reaches far beyond today.