Scientist I - RNAi Discovery

Facility:  Research

Lexington, MA, US

About the Department

Dicerna, a Novo Nordisk company, is focused on driving innovation in RNAi (ribonucleic acid interference) to selectively target and silence genes that cause or contribute to disease. Our proprietary GalXC™ and GalXC-Plus™ RNAi technologies have the potential to address conditions that are difficult or impossible to treat with other modalities. Established as a Transformational Research Unit (TRU) following Novo Nordisk’s acquisition of Dicerna Pharmaceuticals, Inc. in December 2021, the Dicerna TRU is a unique new organization within Novo Nordisk that brings together the best of both worlds – the agility, collaborative pioneering spirit and calculated risk-taking profile of a biotech along with the scale, resources and capabilities of a global leader in drug development. With approximately 200 researchers, scientists, drug developers and operational staff, we are a team of inventive and entrepreneurial thinkers pushing the boundaries of science to create and drive new RNAi-based therapies for both rare and more prevalent diseases from the bench to the clinic. Together, we are driving change. Are you ready to make a difference?


The Position

The Scientist, RNAi Discovery will be a key member of Dicerna's biology teams and will engage in multiple internal and partnered research and discovery efforts. Dicerna is seeking a highly motivated, experienced Ph.D. scientist to help in our siRNA drug discovery efforts. This is a hands-on research position that requires strong expertise in molecular and cellular methodologies. Major responsibilities will include the design and execution of siRNA drug candidate screening to evaluate in vitro and in vivo activity of hits and lead candidates, while interacting closely with members of the RNAi Discovery group and other biology and chemistry teams. You will apply your expertise in molecular and cellular biology to develop and execute assays for the evaluation of candidate RNAi therapeutics. In addition, you will perform mechanistic studies to further optimize and expand Dicerna's RNAi technology platform.



This position reports to the Senior Director, Systems Biology


Essential Functions

  • Lead and execute wet lab-based in vitro and in vivo experiments within cross functional teams (including computational biologists, high-throughput screening, in vivo pharmacologists.)
  • Drive next-generation sequencing projects (e.g., RNA-Seq) from conception to data analysis and interpretation
  • Develop new high-throughput methods to enable the characterization of drug candidates


Physical Requirements

0-10% overnight travel required.



  • PhD in molecular biology, genetics, or related discipline with 1 or more years post-PhD experience in an academic or biopharma/biotech setting
  • 3+ years of hands-on molecular biology experience
  • Demonstrated expertise with in vitro (cell culture and cell free) and in vivo (rodent models) methods, including generating high-quality samples for high-throughput sequencing analysis (particularly RNA-seq)
  • Demonstrated expertise with generating samples high-throughput sequencing analysis – particularly RNA-Seq
  • Expertise with RNA biology is a plus
  • Experience with RNAi is a plus
  • Working knowledge of computational and statistical approaches for high-dimensional data analysis (especially bulk RNAseq) is preferred


We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.


At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.


Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.


Novo Nordisk requires all new hires to be fully vaccinated against COVID-19 prior to the first date of employment. As required by applicable law, Novo Nordisk will consider requests for reasonable accommodation.


If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.