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Scientist II - Integrated Cell Models & Cell-Based Therapies

Facility:  Research
Location: 

Indianapolis, IN, US

About the Department                                                                                                                                     

The Novo Nordisk Research Center Indianapolis, Inc. (NNRCII) supports our global mission to transform the treatment of chronic diseases through the discovery of high-quality drug candidates and disruptive technology innovations. We operate as a Transformational Research Unit (TRU), meaning we are a relatively small team of elite interdisciplinary researchers working in unison yet with autonomy relative to the global R&D organization—essentially a biotech-like ecosystem within the Novo Nordisk biosphere. We have multiple strategic collaborations with internationally acclaimed academic centers of excellence and emerging biotech’s, which we view as an integral part of our discovery research process and essential for our fundamental scientific endeavors. Collectively, this allows us to focus our efforts on data generation and translation of research hypotheses to foster quick data-driven, non-stochastic decisions. 

We are keenly focused on grassroot discovery projects pertaining to cardio-metabolic diseases and rare endocrine disorders, and we are responsible for driving projects from ideation to clinical development. In addition to drug discovery research, we also explore novel chemical biology technologies to optimize the therapeutic applications of peptides/proteins as well as biotechnologies that catalyze the pursuits of therapeutic modalities new to Novo Nordisk.  Are you ready to make a difference?

 

The Position

The Scientist II will provide scientific leadership in the identification and validation of new drug targets, advancing novel therapies to the clinic, and developing novel cellular technologies and therapies to accelerate drug research. This will be achieved by coordinating multiple research activities involving cross-functional project teams to ensure achievement of key deliverables. The Scientist II will represent the organization to the external scientific community through publication and presentation of research and through participation in external collaborations.

 

Relationships

Reports to of the Site Head of Novo Nordisk Research Center Indianapolis & Senior Director of the Transformational Research Unit-Chemical Biology. 
Internal relationships include project teams and research colleagues in Seattle, Indianapolis, Denmark, and around the globe. Communicates data externally when required. Close relationships with Stem Cell Research & Development. Individual Contributor: does not manage other employees or contingent workers.

 

Essential Functions

  • Advances research projects by demonstrating biological and technical expertise, creativity, and scientific leadership in human cell-based technologies, including stem cells, and their applications to drug discovery and characterization.
  • Evaluate the characteristics, validity, and scalability of novel models of gastric and intestinal tissues, including stem cell derived organoids and microfluidic setups, to assess drug absorption, transport, and metabolism to predict oral bioavailability of biologic-based drug candidates
  • Spearhead local discovery research efforts aimed at ideation and evaluation of cell-based therapies for metabolic and endocrine disorders
  • Analyzes complex data with high degree of sophistication, connecting disparate datasets to reach conclusions and set direction on experiments. Contributes strong scientific acumen to enable projects and advance the research agenda.
  • Effectively communicates and collaborates across global sites and guides project strategy by providing leadership of cross-functional project teams. Represents the organization through external communication of impactful scientific research in the form of presentation at external conferences and publication in scientific journals and patents. May manage external collaborations.
  • Maintains a strong understanding of theoretical knowledge and a connection to the external scientific community through continuous evaluation of relevant literature. Expands the capabilities of cell-based assays and discovery biology through the generation of new ideas, evaluation of new cellular methodologies, and implementation of cell-based assay and therapy strategies that add value.
  • Leads cross-functional experimental teams to achieve project goals, mentor junior staff, and provide training.
  • Influences the research pipeline by proposing new projects that support the strategic agenda.

 

Physical Requirements:
Novo Nordisk requires all employees, both Field and Office-based, to be fully vaccinated with a COVID-19 vaccine prior to the first date of employment. As required by applicable law, Novo Nordisk will consider requests for reasonable accommodation for those unable to be vaccinated. You will be required to upload an image of your COVID-19 vaccine card at the time of hire and/or on your first day of employment

 

Qualifications

  • Bachelor 's degree with 15+ years’ relevant experience required Degree in cell biology, cellular biotechnology, or cellular biotherapy preferred.
    • OR Doctoral degree with 4+ years’ post-doctoral and/or industry relevant experience or Master’s degree with 10+ years’ relevant experience can be considered.
  • Relevant required experience includes some combination of: 
    • Strong hands-on experience with stem cell cultivation, differentiation, and characterization 
    • Strong experience with stem cell-based assay development that involves complex organoids with requisite heterogeneity
    • Experience with microfluidic devices to be leveraged for cell-based assays to assess drug function and cellular uptake
    • Experience with evaluating drug absorption and transport using in vitro based cell assays
    • Experience with conceptualizing and evaluating cell-based therapies for utility in obesity, diabetes, NASH, cardiac fibrosis and other endocrine disorders
    • Strong written and oral communication skills.
  • Preferred experience includes:
    • Strong publication and patent track record

 

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. 

 

At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

 

Novo Nordisk is an equal opportunity employer.  Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.

 

If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.